The molecular mechanisms underlying diabetic complications
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چکیده
منابع مشابه
The molecular mechanisms underlying diabetic complications
Diabetes mellitus is one of the most common chronic diseases worldwide and is associated with an increased morbidity and mortality. Diabetes is characterized by chronic hyperglycemia and alterations of cellular homeostasis, which lead to diffuse vascular damage. The microvascular complications of diabetes, resulting from a damage of the microvasculature of the kidney, retina and neurons, includ...
متن کاملMolecular mechanisms of diabetic vascular complications
Diabetic complications are the major causes of morbidity and mortality in patients with diabetes. Microvascular complications include retinopathy, nephropathy and neuropathy, which are leading causes of blindness, end-stage renal disease and various painful neuropathies; whereas macrovascular complications involve atherosclerosis related diseases, such as coronary artery disease, peripheral vas...
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Vascular complications are a major cause of morbidity and mortality in patients with diabetes mellitus. Diabetic microvascular complications include diabetic retinopathy, neuropathy and nephropathy. Hyperglycaemia-induced activation of metabolic pathways, hyperglycaemia-induced growth factors, components of metabolic syndrome and hyperglycaemia-induced epigenetic changes act through a common pl...
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It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic required, but also for its major complications, affecting both small and large blood vessels. These complications occur in the majority of individuals with both type 1 and type 2 diabetes. Among the most prevalent microvascular complications are kidney disease, blindness, and amputations, with curren...
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Pluripotency and self renewal are the two primary characteristics of pluripotent stem cells (PSCs) [1]-[4]. Pluripotency refers to the capacity of a single cell to give rise to any cell type of an embryo or an adult animal [5],[6]. A mammalian organism is developed from a single fertilized egg, the zygote, in an extremely ordered and error-proof fashion [7]. The zygote and the subsequent 2 to 4...
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ژورنال
عنوان ژورنال: International Journal of Pediatric Endocrinology
سال: 2013
ISSN: 1687-9856
DOI: 10.1186/1687-9856-2013-s1-o1